Flucloxacillin Sodium A Penicillin Group Antibiotic -Some Facts

Flucloxacillin Sodium A Penicillin Group Antibiotic -Some Facts

  • Flucloxacillin is 3-(2′-chloro-6′-fluorophenyl)-5-methyl-4-isoxazolylpenicillin monohydrate. It is a member of the beta-lactamase-stable group of penicillins derived from the penicillin nucleus, 6-amino-penicillanic acid.
  • Flucloxacillin is closely related to cloxacillin.
  • The chemical formula of flucloxacillin sodium is C19H16ClFN3NaO5S,H2O. Its molecular weight is 93.9 and its CAS registry number is 1847-24-1.
  • Flucloxacillin sodium is a white or almost white, crystalline powder, hygroscopic, freely soluble in water and in methanol, soluble in alcohol
  • Flucloxacillin sodium, a derivative of 6-amino-penicillanic acid, is a semi-synthetic penicillin with a narrow spectrum of bactericidal activity.
  • Flucloxacillin, by its action on the synthesis of the bacterial wall, exerts a bactericidal effect on streptococci, staphylococci, including the beta-lactamase-producing strains, clostridia and neisseria. It is not active against methicillin-resistant staphylococci.
  • Strains of the following organisms are generally sensitive to the bactericidal action of flucloxacillin in vitro (the minimal inhibitory concentrations (MIC) of flucloxacillin are also quoted below).
  • FLUCLOXACILLIN is indicated for the treatment of infections due to Gram-positive organisms, including infections caused by β-lactamase producing staphylococci

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